Institutional Animal Care and Use Committee

Responsibilities: PIs will receive electronic notification of the upcoming annual review date two months in advance. It is the PI’s responsibility to ensure that the annual reviews are submitted in sufficient time for the IACUC to review and approve the reviews by the expiration date.

How to submit an annual review in eSirius

• You will find an alert on your e-Sirius home page 60 days before the annual review date of your protocol, under the “Alerts- Protocol Annual Reviews” section. To start the process, click on the Protocol number (in blue).
• On the next page, indicate what you would like to do with your protocol in the Review Action Section, and provide a brief progress report.
  • If you select:
    • Research continues as previously approved- you will see a signature page.
    • Research Continues with modification- you will continue with an amendment submission
    • Research withdrawn- you will be required to state the disposition of your animals

Responsibilities: PIs will receive electronic notification of the upcoming expiration of their protocols 5 months in advance. It is the PI’s responsibility to ensure that the renewal requests are submitted in sufficient time for the IACUC to review and approve the renewal by the expiration date. The IACUC will conduct a full review of the protocol upon submission.

How to submit a three year renewal in eSirius

1. Click on https://esirius.research.cornell.edu/esirius/
2. In the section "Alerts- 3rd year review", you will find a listing for the expiring protocol(s).
3. To start the three year renewal, click on the Protocol number (in blue).
   
   **DO NOT SELECT THE OPTION "Create a protocol from an existing protocol". This will assign a new protocol number to your 3 year renewal application.
   
   
4. On the next page enter a brief progress report on your protocol. Indicate if the protocol will be renewed, or will lapse/terminate upon expiration.
5. To renew the protocol: select the pages from your original protocol that you want to copy into your resubmission. This will bring the information from the relevant pages into the form that you will be working on.
6. Carefully update, add or remove the information on this protocol as if you were submitting a new protocol. For example if you adding species, procedures, locations etc., select the appropriate sections of the protocol to make changes.
7. You can save this protocol and update it later. You will find the protocol in the "Unfinished Protocols" section with a document type of "Full Review"
8. When you are done making your changes, your protocol will retain the same protocol number as the original one.
9. To terminate the protocol: indicate the disposition of the animals. The protocol will continue to appear on your home page in "IACUC" status until the IACUC Administrator approves the termination. Once the protocol is terminated, you will receive a notification from eSirius to that effect.
10. Complete the information on your protocol and submit to the IACUC. You will receive an email confirmation when the protocol has been submitted. The protocol will no longer be in "Unfinished" status.
11. The IACUC will put your protocol on the agenda for the next IACUC meeting and review your protocol as a new submission. During this time, the protocol will continue to be on your eSirius home page in "IACUC" status.