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Frequently Asked Questions (FAQ)

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General Questions: ^Top

  1. I am a new investigator at Cornell. What do I need to do before beginning animal research?
  2. What is an IACUC?
  3. What is the difference between CARE and IACUC?
  4. When do I need to submit an IACUC protocol application?
  5. What is LAS?
  6. What is ORIA?
  7. What is the relationship between IACUC and ORIA?
  8. Is Cornell AAALAC accredited?

eSirius: ^Top

  1. What is eSirius
  2. Who can use eSirius?
  3. How do I get access to eSirius?
  4. When and where are the training sessions for eSirius?
  5. Who do I call for problems or questions about eSirius?

Online Protocol Submission with eSirius: ^Top

  1. How are protocols submitted for IACUC Review?
  2. What can be submitted through eSirius?
  3. How do I get access to eSirius?
  4. Who is eligible to submit an animal protocol application?
  5. Can I let other people fill out my protocols?
  6. How do I know I submitted the protocol properly in eSirius?
  7. How do I keep track of the progress of my newly submitted protocol?
  8. Who do I call for problems or questions about eSirius?

IACUC Specific Questions: ^Top

  1. What is the review process by the IACUC?
  2. How often, and when, are the submission deadlines?
  3. How long is the protocol review process in eSirius?
  4. Can my protocol or amendment be expedited?
  5. How do I know when I can expect an approval?
  6. Will I be notified of the expiration, continuation, and renewal dates?
  7. My protocol is past due for annual review. What should I do?
  8. How often do I need to renew my animal protocol?
  9. My protocol is past due for its 3-year renewal. What should I do?
  10. What happens if my protocol is inactivated or expires?
  11. What if my funding agency isn't listed on the dropdown in the External Funding List section?
  12. How do I amend my protocol?
  13. Where can I get assistance in completing a protocol?
  14. Who do I call for problems or questions about eSirius?

Protocol Content Related Questions: ^Top

  1. Do I need to fill out all sections of a protocol?
  2. What does the IACUC expect in the:
    1. Justification of Numbers section of my protocol?
    2. Alternatives section of my protocol?
    3. Lay Abstract section of my protocol?
    4. Scientific Design section of my protocol?
    5. Overview of Procedures section of my protocol?
  3. My research involves procedures that might deviate from the Guide or the Ag Guide. What should I do?
  4. My research involves client owned animals. What should I do?

Personnel & Training Related Questions: ^Top

  1. How can I add a person to my protocol?
  2. What kind of training is required for new personnel?
  3. Who should be listed on my protocol?
  4. What are the minimum IACUC certification requirements for personnel listed on my protocol?
  5. What are the IACUC requirements that must be completed to get keys and access to animal facilities?
  6. When and where are the training sessions for eSirius?

Amendment Specific Questions: ^Top

  1. When is an amendment to my protocol required?
  2. Should I amend my existing protocol or submit a new application?
  3. How do I submit an amendment to my protocol?
  4. I submitted an amendment in eSirius. Does that mean I can proceed with the changes I proposed?
  5. I am not sure which sections to complete for the type of amendment I am making. Where can I get help?
  6. Can I submit additional amendments to my protocol while I already have an amendment pending approval?
  7. How does the IACUC know which changes I am making in the protocol?
  8. I submitted an amendment but no longer want it processed. What are my options?
  9. There is an animal care emergency that requires a change to my protocol. Can I proceed without getting approval for an amendment?
  10. Can amendments be expedited?
  11. Who do I call for problems or questions about eSirius?



General Questions: ^Top

  1. I am a new investigator at Cornell. What do I need to do before beginning animal research?

    There are several things that you need to do:

    1. Read the Cornell Animal Care and Use Policy 1.4, and understand your responsibilities.
    2. Complete Training –both Module I and facility specific Module 2
    3. Get access to eSirius by completing this form.
    4. Submit a new IACUC Protocol (or be added to an Approved Protocol)
    5. Enroll in the Animal Users Health & Safety Program (AUHSP)
    6. Complete a Facility access request form for the facility where you want to house animals.

    For more information on the training requirements see the IACUC policy on training. For more information on Protocol submission see the Protocol Submission FAQ.

    For animal users listed on protocols the AUHSP Process is diagrammed here. AUHSP clearance is NOT a condition for approval of the protocol, but is a condition for access to animal facilities.

    For information on whom to contact for facility access ask CARE@cornell.edu. For more information on how to have members of your research group work with animals see the Animal Facilities Access Checklist.

  2. What is an IACUC?

    Institutional Animal Care and Use Committee. An IACUC is required by federal law. The Cornell IACUC is responsible for independent oversight of the Animal Care and Use program at Cornell University, and monitoring its compliance with applicable federal and state regulations and appropriate guidelines IACUC Membership and Responsibilities

  3. What is the difference between CARE and IACUC?

    The Cornell Center for Animal Resources and Education (CARE) is a service and a resource to the Cornell research and teaching community. The mission of CARE is to ensure animal welfare and facilitate research and teaching. CARE provides high quality animal care and veterinary services. CARE advises and educates researchers, staff and students on animal experimentation issues, promoting best practices for the responsible use of animals.

    All teaching and research activities involving the use of vertebrate animals are reviewed and approved by the IACUC before any animals can be procured and work can begin. In addition to providing oversight over the animal care and use program in a variety of ways (Animal Care and Use Policy 1.4), the IACUC also serves as a resource to faculty, investigators, technicians, students, staff, and administrators, providing guidance in fulfilling the obligation to plan and conduct all animal use procedures with the highest scientific, humane and ethical principles.

  4. When do I need to submit an IACUC protocol application?

    A protocol needs to be submitted if you will be conducting research or teaching for which you need to obtain or use live animals (all warm and cold-blooded vertebrates). If you are only doing in vitro work you do not need to submit a protocol. **If you are collaborating with a colleague at Cornell or another institution, and are PI or Co-PI on the grant funding the work, you must be listed on a Cornell IACUC approved protocol, and provide the approval letter for your colleague’s protocol before grant funds can be released.

  5. What is LAS?

    Cornell Labratory Animal Services (LAS) is an organization providing quality animal care for a wide variety of animals in several specialized facilities.

  6. What is ORIA?

    Office of Research Integrity and Assurance (ORIA) is responsible for many areas of research compliance at Cornell. Government regulations stipulate that when using humans, animals, or recombinant DNA in research, investigators must observe rules mandating responsible conduct in research.

  7. What is the relationship between IACUC and ORIA?

    ORIA provides the administrative support for the IACUC. It houses the IACUC directorate that supports Animal Protocol submission and review through eSirius. ORIA also supports the compliance functions that are necessary for the NIH Office of Laboratory Animal Welfare (OLAW) Assurance for Cornell and Cornell’s research registration with the United States Department of Agriculture (USDA).

  8. Is Cornell AAALAC accredited?

    Yes. Cornell has been fully AAALAC accredited since fall 2003. AAALAC accreditation visits occur on a 3-year cycle, and the next one will take place in 2012.

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eSirius: ^Top

  1. What is eSirius?

    eSirius is a web based content management system that Cornell University currently uses to manage the submission, review, and approval of protocols concerning the use of non-human vertebrates. In addition, eSirius provides functionalities for ordering animals, invoicing, and census data in participating Cornell animal facilities. The eSirius content management system also provides reports to support the state and federal compliance and monitoring functions of IACUC, CARE, and ORIA.

  2. Who can use eSirius?

    Principal Investigators, and anyone affiliated with Cornell University whom the Principle Investigator delegates responsibility to enter protocol information or order animals can use eSirius. A Cornell NetID is required for access to eSirius.

    In addition, members of the IACUC, and staff in various offices which support the IACUC use eSirius on a regular basis, as do staff in animal facilities.

  3. How do I get access to eSirius?

    Download and complete the System Access Form, and submit it to the eSirius Administrator. A Cornell NetID is required for access to eSirius.

  4. When and where are the training sessions for eSirius?

    Training for eSirius is currently under development. A PI Training Manual is available in pdf format, and brief information on how to submit an annual review, and on how to submit a 3-year re- submission are available on the IACUC web site. Both a guide for completing Narrative sections, and an Amendment Guide are also currently available. If you have suggestions for what training and training materials should be available contact the IACUC Administrator.

  5. Who do I call for problems or questions about eSirius?

    For protocol and amendment content related problems and questions, first consult the protocol Narrative Guide, and the Amendment Guide, help documents, and then contact the IACUC Administrator.

    For technical problems, or questions about the functioning of eSirius software, contact the eSirius Administrator, 255-6086.

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Online Protocol Submission with eSirius: ^Top

  1. How are protocols submitted for IACUC Review?

    Animal Use (IACUC) Protocols are submitted on-line using eSirius.

    After you have entered the protocol information and you successfully completed the ‘Error Verification’ process in eSirius, when you click on the ‘Submit to the IACUC Office’ button on the Submit Protocol Page in eSirius the protocol is submitted for IACUC Review. Until you click on the Submit button you can still add and edit protocol information. The process is similar for Amendments, and for annual reviews. See the PI Training Manual pages 16 & 24 et seq. for more detailed information.

  2. What can be submitted through eSirius?

    New protocols, 3-year renewals of protocols, continuing review forms with annual progress reports, and protocol amendments can all be submitted through eSirius.

  3. How do I get access to eSirius?

    Download and complete the System Access Form, and submit it to the eSirius Administrator. A Cornell NetID is required for access to eSirius.

  4. Who is eligible to submit an animal protocol application?

    The policy of Cornell University is that only full-time faculty members may routinely serve as Principle Investigators or Project Directors on sponsored programs. Certain other titles are allowed to serve as Principle Investigators under special circumstances. View the IACUC PI Eligibility Policy for further information.

  5. Who can fill out my protocols?

    Yes. Members or your staff or laboratory may have access to eSirius and enter information into unfinished protocols. As PI you are the only one who can actually “submit” the protocol to IACUC. In doing so you agree to abide by the various university, state, and federal policies and guidelines which apply to the use of live animals in research and teaching.

  6. How do I know I submitted the protocol properly in eSirius?

    If you have completed the 'Error Verification' process in eSirius which checks to see that all the required fields are complete, and filled in any required fields that you missed, then from a technical point of view when the "Submit to the IACUC Office" button is clicked, the protocol has be properly submitted. However, this does not necessarily mean that all of the content information which the IACUC will need is in the protocol. Following both the pre-review and IACUC meeting review processes you may need to add or modify the information in the protocol. When the protocol is APPROVED you will get an official notification of the approval. See also How do I know when I can expect an approval?

  7. How do I keep track of the progress of my newly submitted protocol?

    The status of your protocols (and of pending amendments) is shown on your eSirius 'Home Page'. The eSirius content management system will also automatically e-mail you notices of changes in protocol (and pending amendment) status.

  8. Who do I call for problems or questions about eSirius?

    For protocol and amendment content related problems and questions, first consult the protocol Narrative Guide, and the Amendment Guide, help documents, and then contact the IACUC Administrator.

    For technical problems, or questions about the functioning of eSirius software, contact the eSirius Administrator, 255-6086.

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IACUC Specific Questions: ^Top

  1. What is the review process by the IACUC?

    Members of the IACUC staff, CARE Veterinarians, the AUHSP working group, and IACUC members will pre-review your protocol approximately three weeks before the scheduled IACUC meeting. Two IACUC members take primary roles when your protocol is discussed at the IACUC meeting. Following the IACUC meeting you will primarily interact with the IACUC office to resolve any remaining issues. See a graphical timeline.

  2. How often, and when, are the submission deadlines?

    Submission deadlines (usually the day after an IACUC meeting) and IACUC Review Meetings (usually the third Thursday) occur once each month throughout the year. See the current Schedule.

  3. How long is the protocol review process in eSirius?

    The review process takes a variable amount of time depending on many factors. The status of the protocol will change over time and you can use eSirius to follow the protocol as it makes its way through the review process.

    Members of the IACUC staff, CARE Veterinarians, the AUHSP working group, and IACUC members will pre-review your protocol or amendment approximately three weeks before the scheduled IACUC meeting. IACUC members may also pre-review your protocol. When the pre-review period is over, the IACUC Administrator will change the status of your protocol so that you may respond to the questions and requests made as part of the pre-review process. You will get an e-mail to this effect. The window of time that you can enter your responses in your protocol in eSirius is approximately one week. The IACUC Administrator will place the protocol on the IACUC Meeting Agenda (usually a week before the scheduled meeting), and you can no longer access it. During the IACUC Meeting additional questions or requests may be generated when your protocol is discussed. Following the meeting the IACUC Administrator will enter these questions and requests into eSirius, and you will be notified regarding the need to respond.

    Your timely and complete response to the pre-reviews is likely to markedly shorten the time between the submission deadline and when you get approval to proceed from the IACUC.

  4. Can my protocol or amendment be expedited?

    If there is a compelling need, the IACUC Chair will review the reason for the request to deem if it warrants an expedited review. If the reason is justified, the protocol or amendment needs to be submitted to the IACUC office for review. Any member of the IACUC can request a full committee review.

  5. How do I know when I can expect an approval?

    The approval process takes a variable amount of time depending on many factors. See a graphical timeline. The status of the protocol will change over time and you can use eSirius to follow the protocol as it makes its way through the approval process. The following is a typical scenario you might expect.

    Creating a New Protocol: When you create a new protocol, it will be in the UN-FINISHED list on your eSirus homepage. You can then take as long as you need to fill out the sections of the protocol. If you click the 'Finish Later' button (on the bottom of each eSirius page) you may log out of eSirius and log back in at a later time, and your UN-FINISHED protocol will be there as you left it. When you think you have all the sections filled out, complete the ‘Error Verification’ process in eSirius which checks to see that all the required fields are complete, and fill in any required fields that you missed.

    Submitting a Protocol: When the ‘Error Verification’ process is complete click the 'Submit to the IACUC Office' button, and the protocol will move to the NEW PROTOCOLS list on your eSirius homepage. Your protocol will enter the Review and Revision process at the next submission deadline date.

    Review and Revision: While the protocol is under review and revision you can see the date of the last action and the type of request that was made on your eSirius homepage. The Error Verification process does not necessarily mean that all of the content information which the IACUC needs is in the protocol. Members of the IACUC staff, CARE Veterinarians, the AUHSP working group, and IACUC members will pre-review your protocol or amendment approximately three weeks before the scheduled IACUC meeting. When the pre-review period is over, the IACUC Administrator will change the status of your protocol so that you may respond to the questions and requests made as part of the pre-review process. You will also get an e-mail to this effect. The time window when you can enter your responses in eSirius is approximately one week. Then the IACUC Administrator will put the protocol on the IACUC Meeting Agenda (usually a week before the scheduled meeting), and you can no longer access it to make changes. During the IACUC Meeting additional questions or requests may be generated when your protocol is discussed. Following the meeting the IACUC Administrator will enter these questions and requests into eSirius, and you will be notified to of the need to respond.

    Your timely and complete response to the pre-reviews will shorten the time between the submission deadline and when you get approval to proceed from the IACUC.

    Approval of the Protocol: When the IACUC is satisfied that all issue have been resolved the protocol will be APPROVED and it will move to your PROTOCOLS list. You will get an official notification of the approval.

  6. Will I be notified of the expiration, continuation, and renewal dates?

    Your approval notification contains the date the protocol will expire (generally three years after the approval date). The need for Annual continuations and for the 3-year Renewal of the protocol will show up in your Alerts on your eSirius homepage. You will also get courtesy e-mail reminders. However, it is the PI’s responsibility to make sure that Annual and 3-year renewals are submitted and approved before the expiration date.

  7. My protocol is past due for annual review. What should I do?

    Contact the IACUC Administrator immediately! You may need to stop all animal work until your annual continuation is approved.

  8. How often do I need to renew my animal protocol?

    You need to file a progress report and continuation Annually. You need to renew your protocol within three years.

  9. My protocol is past due for its 3-year renewal. What should I do?

    Cease all animal work immediately, and contact the IACUC Administrator. Any animals that you still have will need to be transferred to another active protocol or humanely euthanized.

  10. What happens if my protocol is inactivated or expires?

    Cease all animal work immediately! Any animals that you still have will need to be transferred to another active protocol or humanely euthanized.

  11. What if my funding agency isn't listed on the dropdown in the External Funding List section?

    Please select "Other" from the dropdown list, and provide the information on the funding agency in the Grant/Contract Title text field along with the title.

  12. How do I amend my protocol?

    On your eSirius homepage click on "Submit an Amendment for an Existing Protocol". Select the protocol you which to amend from the List of Approved protocols, and click "Continue". Tick the checkboxes for the sections you will need to change, and click "Next". Complete the "Justification" section to let the IACUC know what your reason(s) for asking for an amendment are. Select and edit sections. See the PI Training Manual pages 18-24 for details on the eSirius pages, and see the Amendment Guide for what sections to complete and what is expected by the IACUC.

  13. Where can I get assistance in completing a protocol?

    For protocol and amendment content help, first consult the protocol Narrative Guide, and the Amendment Guide, help documents. The IACUC Office (contact the IACUC Administrator) and CARE (see CARE Help) are both available to provide assistance.

    For technical with eSirius first consult the PI Training Manual, then, contact the eSirius Administrator, 255-6086.

    Experienced investigators and members of research groups in your department may also be a source of assistance.

  14. Who do I call for problems or questions about eSirius?

    For protocol and amendment content related problems and questions, first consult the protocol Narrative Guide, and the Amendment Guide, help documents, and then contact the IACUC Administrator.

    For technical problems, or questions about the functioning of eSirius software, contact the eSirius Administrator, 255-6086.

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Protocol Content Related Questions: ^Top

  1. Do I need to fill out all sections of a protocol?

    Required pages in eSirius will be marked by a red bullet on the Table of Contents (left menu) in eSirius if you have not visited these pages. Within each page required sections (fields) in eSirius are marked with a red star (*), although often on the extreme right side of the screen All these required sections (fields) on the eSirius Protocol pages must be completed. Enter "Not Applicable" or NA if the section is not relevant to your use of animals. It is wise to mark even non-required sections NA, so that the IACUC knows that you considered the section.

  2. What does the IACUC expect in the:
    1. Justification of Numbers section of my protocol?

      Explain how you determined the number of animals required for the activities described in this protocol. Be sure that the numbers in this justification match the animal numbers in 13.1 and 13.12., and correspond with 5. Scientific Design. (Note: Approved numbers may not be exceeded without an amendment.) When your choice of species, strain or experimental model allowed reduction in numbers, include this information in the justification.

      Whenever possible, the number of animals must be justified statistically with a power analysis. Certain kinds of activities (e.g. teaching, exploratory research, harvest of tissues for in vitro research) are not amenable to a power analysis. In such cases a rational basis for the number of animals requested must be provided. See Justification of Numbers Help for examples, and for resources for statistical analysis.

    2. Alternatives section of my protocol

      Consult what the IACUC expects. In brief, provide a written narrative description of methods and sources used to consider alternatives to procedures that may cause more than momentary or slight pain or distress to animals. State how you determined that alternatives were not available.

      Address the 3 R’s – Replacement (with non-animal systems, or species lower on the phylogenetic scale), Refinement (decreasing or eliminating pain or distress), and Reduction (in number of animals necessary).

      If database searches are carried out, more than one database must be searched. See a more detailed Help Document for search strategies, resources, requirements, and examples.

      If your protocol has animals from more than one species in USDA categories D or E, please provide separate information for each species.

    3. Lay Abstract section of my protocol?

      (250 words or less) Briefly describe the major goals of the research and why the animal model you chose is the appropriate model. Write in non-technical language. All abbreviations/acronyms should be defined on first use. For example, how would you describe your work to a group of high school students? Be clear and concise; several sentences to one or two short paragraphs should be adequate.

    4. Scientific Design section of my protocol?

      Provide scientific justification for your experimental design, focusing on the use and need for animals to achieve your goals. This will be of variable length depending on the design complexity. For instructional protocols describe the exercises which involve the use of animals, and how this relates to the goals of the courses (attach a course syllabus). The purpose of this section is to enable the committee to evaluate how the proposed work or activity affects animal welfare, and whether the use of animals is appropriately justified. Details of post mortem procedures are not required and should not be provided.

      Please do not simply attach a copy of your grant proposal!

    5. How do I write the overview of Procedures section of my protocol?

      Describe the order of procedures to be performed on live animals, so the IACUC can evaluate the impact on the animals, as related to animal welfare. Provide a timeline and/or a sequential list of all procedures (e.g. blood collection, surgery, behavioral training, administration of substances or test compounds, breeding, tumor induction etc.) to be performed on all live animals. Details of the procedures will be requested in subsequent sections and should not be incorporated here.

  3. My research involves procedures that might deviate from the Guide or the Ag Guide. What should I do?

    Consult a Care Veterinarian or contact CARE@cornell.edu. If, based on the consultation, it seems likely that an Exemption from Standards of Care will be needed, complete or amend Section 13.14 Exemptions from Standards of Care in your protocol. The final determination of whether deviations from the Guide or Ag Guide are needed, and are justified rests with the IACUC at a regularly scheduled meeting. Note: Cornell reports Exemptions from Standards of Care to the USDA annually, and that the USDA may be required to release this information to the public under the Freedom of Information Act (FOIA).

  4. My research involves client owned animals. What should I do?

    Complete or amend Section 13.3 Species Source in your protocol to indicate that client owned animals will be used. Be sure to attach a Client Consent Form to the protocol. Protocols using client owned animals will not be approved by the IACUC without reviewing the client consent form.

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Personnel & Training Related Questions:

  1. How can I add a person protocol?

    For information on how to have members of your research group work with animals see the Animal Facilities Access Checklist. Briefly - The PI needs to amend the protocol (see Changes in Personnel Information), accordingly:

    1. Read the Cornell Animal Care and Use Policy 1.4, and understand their responsibilities.
    2. Complete Training –both Module I and facility specific Module 2
    3. Enroll in the Animal Users Health & Safety Program (AUHSP)
    4. Complete a Facility access request form for the facility where you house animals.

    For animal users listed on protocols the AUHSP Process is diagrammed here. AUHSP clearance is NOT a condition for approval of the protocol, but is a condition for access to animal facilities. For information on whom to contact for facility access ask CARE@cornell.edu.

  2. What training is required for new personnel?

    Both Module I and facility specific Module 2 training are required of all personnel working with animals. The IACUC may require additional training before they are allowed to work with animals depending on the procedures they will perform. For more information on the training requirements see the IACUC policy on training.

  3. Who should be listed on my protocol?

    Anyone who will be carrying out procedures on the animals covered by your protocol needs to be listed on the protocol, and the procedures they will be performing identified. Clinical staff who are performing routine clinical care do not need to be listed. Facility staff that are performing procedures specifically required by your research or teaching that go beyond routine clinical care need to be listed on your protocol.

  4. What are the minimum IACUC certification requirements for personnel listed on my protocol?

    See How can I add a person to my protocol?

  5. What are the IACUC requirements that must be completed to get keys and access to animal facilities?

    See How can I add a person to my protocol?

  6. When and where are the training sessions for eSirius held?

    Training for eSirius is currently under development. A PI Training Manual is available in pdf format, and brief information on how to submit an annual review, and on how to submit a 3-year re- submission are available on the IACUC web site. Both a guide for completing Narrative sections, and an Amemendment Guide are also currently available. If you have suggestions for what training and training materials should be available contact the IACUC Administrator.

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Amendment Specific Questions: ^Top

  1. When is an amendment to my protocol required?

    Whenever you make a change to the protocol. This includes: changes in personnel carrying out procedures on the protocol; additions to animal numbers, changes to animal numbers in any of the USDA categories, changes or additions to any procedures (non-surgical procedures, surgeries, restraints, euthanasia methods), change in drugs, hazardous agents, changes to animal housing or procedure locations.

  2. Should I amend my existing protocol or submit a new application?

    If your overall scientific goal(s) remain the same you should submit an amendment to cover any changes in the use of animals, including a change in animal species. A new protocol application is required when your scientific goals change - or if you are changing from non-survival to survival surgery. (See Policy 1.4 page 19 #8) A new protocol is suggested if the changes in the use of animals are extensive (you will be making significant changes to nearly all protocol narrative sections).

  3. How do I submit an amendment to my protocol?

    On your eSirius homepage click on "Submit an Amendment for an Existing Protocol". Select the protocol you which to amend from the List of Approved protocols, and click "Continue". Chec the appropriate boxes for the sections you will need to change, and click "Next". Complete the "Justification" section to let the IACUC know what your reason(s) for asking for an amendment are. Select and edit sections. See the PI Training Manual pages 18-24 for details on the eSirius pages, and see the Amendment Guide for what sections to complete and what is expected by the IACUC.

    If you click the 'Finish Later' button (on the bottom of many eSirius page) you may log out of eSirius and log back in at a later time, and your UN-FINISHED amendment will be there as you left it. Be aware that if you are amending sections of a protocol you cannot start a second amendment that involves any of those “active sections”.

  4. I submitted an amendment in eSirius. Does that mean I can proceed with the changes I proposed?

    NO!! IACUC must approve amendments before you can proceed with the changes. Removing personnel can be done administratively, if remaining personnel are qualified/trained to carry out all the procedures.

  5. I am not sure which sections to complete for the type of amendment I am submitting. Where can I get help?

    For amendment content help, first consult the protocol Amendment Guide, and the Narrative Guide help documents. The IACUC Office (contact the IACUC Administrator) and CARE (see CARE Help) are both available to provide assistance.

  6. Can I submit additional amendments to my protocol while I already have an amendment pending approval?

    Yes if your additional amendment does NOT involve sections of the protocol you have changed in the pending amendment submission.

  7. How does the IACUC know what changes I am making in the protocol?

    The changes that you have made to the protocol show up in the review process in blue for additions, and in red/strike through for deletions to the protocol. Many pages also show with a tracking box which indicates changes, or completely new additions to sections.

  8. I submitted an amendment but no longer want it processed. What are my options?

    Contact the IACUC Administrator. Amendments can be withdrawn administratively prior to approval.

  9. There is an animal care emergency that requires a change to my protocol. Can I proceed without getting approval for an amendment?

    Coordinate immediately, and closely, with the appropriate CARE (or CARE designated) veterinarian. Emergency CARE Contact Information. They are authorized to provide emergency veterinary care including changes to your approved procedures that will reduce pain, distress or illness in animals. They are also authorized to euthanize animals exhibiting unbearable pain, distress or illness (even if euthanasia was not authorized as part of your protocol).

    Report any unanticipated pain or distress, morbidity, or mortality to the appropriate CARE (or CARE approved) veterinarian, notify the IACUC of any significant unexpected events that affect the welfare of the animals. Contact the IACUC to see if an amendment to your protocol will be required. Guidance can also be provided by CARE.

  10. Can amendments be expedited?

    If there is a compelling need, the IACUC Chair will review the reason for the request to deem if it warrants an expedited review. If the reason is satisfactory, the protocol or amendment needs to be submitted to the IACUC office for review. Any member of the IACUC can request that the review be deferred to a full committee meeting.

  11. Who do I call for problems or questions about eSirius?

    For protocol and amendment content related problems and questions, first consult the protocol Narrative Guide, and the Amendment Guide, help documents, and then contact the IACUC Administrator, 255-2214.

    For technical problems, or questions about the functioning of eSirius software, contact the

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AUHSP Specific Questions: ^Top

  1. 1. What is AUHSP?

    Animal Users Health & Safety Program (AUHSP). The AUHSP evaluates the human-health risks associated with direct and indirect contact with animals used in research and teaching at Cornell. The objective of the AUHSP is to ensure that health risks for every individual are managed to an acceptable level. The AUHSP is predicated on the assessment of risk.

    Responsibility for the AUHSP is among five principal units: the Institutional Animal Care and Use Committee (IACUC), the Cornell Center for Animal Resources and Education (CARE), Environmental Health and Safety (EH&S), the Office of Research Integrity and Assurance (ORIA) and Gannett Health Services (Gannett).

    The AUHSP Coordinating Committee, comprised of the directors of the five principal units, administers the program. The Coordinating Committee has responsibility for establishing institutional occupational health and safety policy and procedures for animal users and other individuals having direct or indirect contact with animals used in research and teaching.

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