Skip to main content


IACUC Main > IACUC Submission Requirements > IACUC P.I. Requirements


Principal Investigator Requirements

The IACUC policy in determining P.I. status can be downloaded here.

Investigators, teachers, students, technicians and staff must be aware that use of animals in research is a privilege governed by public concerns, federal, state and local regulations, and Cornell University policies. It is a violation of federal regulations to carry out studies using vertebrate animals without an approved protocol or to maintain animals after expiration of a previously approved protocol.

No activity involving animals may be conducted or supported by the United States Public Health Service (PHS) until the institution conducting the activity has filed a written Animal Welfare Assurance Statement of Compliance with the Office of Laboratory Animal Welfare (OLAW), National Institutes of Health. Our assurance is applicable to all activities involving live vertebrate animals by Cornell University faculty or staff at any location.

Cornell University’s assurance with OLAW stipulates our commitment to quality care when using animals. The assurances specify our institutional responsibilities which include defining lines of responsibility and authority, monitoring animal care and use, providing veterinary care, record keeping, appropriate environment and housing of animals, personnel training, and establishing an appropriateoccupational health and safety program. We use the Guide for the Care and Use of Laboratory Animals (“The Guide”) published by the National Academy Press (1996) as a basis for developing and implementing our institutional program for activities involving animals.

All individuals working with animals at Cornell University should be familiar with the Cornell Center for Animal Resources and Education (CARE). CARE is a group of veterinarians, veterinary technologists, and support staff, dedicated to the welfare of animals used in research and teaching at Cornell University. CARE ensures that high quality care is provided for all research animals, and that they are used in compliance with federal, state, and local regulations and guidelines. CARE is a service to the Cornell research community, providing clinical veterinary care to the research animals, and advising investigators on animal experimentation issues, such as analgesia, anesthesia, surgery, and method development.

The Cornell University Institutional Animal Care and Use Committee (IACUC) must review and approve all animal use at Cornell University. The IACUC oversees the animal use program as mandated by the PHS Policy and Animal Welfare Act (AWA). Individuals should be aware of their individual and collective responsibilities for compliance with laws and regulations pertaining to animal care and use.